Functional and Pathogenic Differences of Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis

@inproceedings{Domingues2010FunctionalAP,
  title={Functional and Pathogenic Differences of Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis},
  author={Helena S Domingues and Marsilius Mues and Hans Lassmann and Hartmut Wekerle and Gurumoorthy Krishnamoorthy},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND There is consensus that experimental autoimmune encephalomyelitis (EAE) can be mediated by myelin specific T cells of Th1 as well as of Th17 phenotype, but the contribution of either subset to the pathogenic process has remained controversial. In this report, we compare functional differences and pathogenic potential of "monoclonal" T cell lines that recognize myelin oligodendrocyte glycoprotein (MOG) with the same transgenic TCR but are distinguished by an IFN-γ producing Th1-like… CONTINUE READING

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