Functional and Morphological Correlates of Connexin 50 Expressed in Xenopus laevis Oocytes

@inproceedings{Zampighi1999FunctionalAM,
  title={Functional and Morphological Correlates of Connexin 50 Expressed in Xenopus laevis Oocytes},
  author={Guido A. Zampighi and Donald Doo Fuey Loo and Michael Kreman and Sepehr Eskandari and Ernest M Wright},
  year={1999}
}
Electrophysiological and morphological methods were used to study connexin50 (Cx50) expressed in Xenopus laevis oocytes. Oocytes expressing Cx50 exhibited a new population of intramembrane particles (9.0 nm in diameter) in the plasma membrane. The particles represented hemichannels (connexin hexamers) because (a) their cross-sectional area could accommodate 24 6 3 helices, (b) when their density reached 300–400/ m m 2 , they formed complete channels (dodecamers) in single oocytes, and assembled… CONTINUE READING

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