Functional and Molecular Aspects of Voltage‐Gated K+ Channel β Subunits

@article{Pongs1999FunctionalAM,
  title={Functional and Molecular Aspects of Voltage‐Gated K+ Channel $\beta$ Subunits},
  author={Olaf Pongs and Thorsten Leicher and Michaela Berger and Jochen Roeper and Robert B{\"a}hring and Dennis Wray and Karl Peter Giese and Alcino J. Silva and Johan Frederik Storm},
  journal={Annals of the New York Academy of Sciences},
  year={1999},
  volume={868}
}
ABSTRACT: Voltage‐gated potassium channels (Kv) of the Shaker‐related superfamily are assembled from membrane‐integrated α subunits and auxiliary β subunits. The β subunits may increase Kv channel surface expression and/or confer A‐type behavior to noninactivating Kv channels in heterologous expression systems. The interaction of Kvα and Kvβ subunits depends on the presence or absence of several domains including the amino‐terminal N‐type inactivating and NIP domains and the Kvα and Kvβ binding… 
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