Functional and Biochemical Rationales for the 24-Hour-Long Duration of Action of Olodaterol

@article{Casarosa2011FunctionalAB,
  title={Functional and Biochemical Rationales for the 24-Hour-Long Duration of Action of Olodaterol},
  author={Paola Casarosa and Ines Kollak and Tobias Kiechle and Angela Ostermann and Andreas Schnapp and Ralf Kiesling and Michael Pieper and Peter Sieger and Florian Gantner},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2011},
  volume={337},
  pages={600 - 609}
}
β2-Adrenoceptor (β2-AR) agonists are powerful bronchodilators and play a pivotal role in the management of pulmonary obstructive diseases, such as asthma and chronic obstructive pulmonary disease. Although these agents first were used many years ago, progress in drug development has resulted in better tolerated, long-acting β2-AR agonists (LABAs), such as formoterol and salmeterol. Although LABAs have been on the market for several years, relatively little is known on the rationale(s) behind… 

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