Functional analysis of yeast snoRNA and snRNA 3'-end formation mediated by uncoupling of cleavage and polyadenylation.

@article{Morlando2002FunctionalAO,
  title={Functional analysis of yeast snoRNA and snRNA 3'-end formation mediated by uncoupling of cleavage and polyadenylation.},
  author={Mariangela Morlando and Paolo Greco and Bernhard Dichtl and Alessandro Fatica and Walter Keller and Irene Bozzoni},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 5},
  pages={1379-89}
}
Many nuclear and nucleolar small RNAs are accumulated as nonpolyadenylated species and require 3'-end processing for maturation. Here, we show that several genes coding for box C/D and H/ACA snoRNAs and for the U5 and U2 snRNAs contain sequences in their 3' portions which direct cleavage of primary transcripts without being polyadenylated. Genetic analysis of yeasts with mutations in different components of the pre-mRNA cleavage and polyadenylation machinery suggests that this mechanism of 3… CONTINUE READING

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