Functional analysis of the secondary HIV-1 capsid binding site in the host protein cyclophilin A

@inproceedings{Peng2019FunctionalAO,
  title={Functional analysis of the secondary HIV-1 capsid binding site in the host protein cyclophilin A},
  author={Wang Gongping Peng and Jiong Shi and Chantal L. M{\'a}rquez and Derrick Lau and James Joseph Walsh and K. M. Rifat Faysal and Chang H. Byeon and In-Ja L Byeon and Christopher Aiken and Till B{\"o}cking},
  booktitle={Retrovirology},
  year={2019}
}
AbstractBackgroundEfficient HIV-1 replication depends on interaction of the viral capsid with the host protein cyclophilin A (CypA). CypA, a peptidylprolyl isomerase, binds to an exposed loop in the viral CA protein via the enzyme’s active site. Recent structural analysis of CypA in complex with CA tubes in conjunction with molecular dynamics simulations identified a secondary CA binding site on CypA that allows a bridging interaction with two hexameric subunits of the assembled CA lattice… CONTINUE READING
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