Functional analysis of the host defense peptide Human Beta Defensin-1: new insight into its potential role in cancer.

@article{Bullard2008FunctionalAO,
  title={Functional analysis of the host defense peptide Human Beta Defensin-1: new insight into its potential role in cancer.},
  author={Rebecca S. Bullard and Willietta Gibson and Sudeep K. Bose and Jamila K Belgrave and Andre C Eaddy and Corey J Wright and Debra J. Hazen-Martin and Janice M. Lage and Thomas E. Keane and Tomas A Ganz and Carlton D. Donald},
  journal={Molecular immunology},
  year={2008},
  volume={45 3},
  pages={839-48}
}
Although it is known that innate immunity is key for protecting the body against foreign agents such as bacteria, little is known about elements of the innate immune system that have anti-tumor activity. Human Beta Defensin-1 (hBD-1), an important component of the innate immune response, is lost at high frequencies in malignant prostatic tissue, while high levels of expression are maintained in adjacent benign regions. In prostate carcinoma, frequent genetic alterations occur in the 8p22-23… CONTINUE READING