Functional analysis of the endothelin-1 gene promoter. Evidence for an endothelial cell-specific cis-acting sequence.

Abstract

Endothelin-1 (ET-1) is a peptide synthesized by endothelial cells both in culture and in vivo. ET-1 induces contraction of smooth muscle cells and stimulates growth in a variety of mesenchymal cell types. We have previously characterized the genomic organization of the ET-1 gene and described its chromosomal localization and promoter region sequence. In… (More)

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@article{Lee1990FunctionalAO, title={Functional analysis of the endothelin-1 gene promoter. Evidence for an endothelial cell-specific cis-acting sequence.}, author={Margaret E. Lee and Kenneth D. Bloch and Jonathan A Clifford and Thomas Quertermous}, journal={The Journal of biological chemistry}, year={1990}, volume={265 18}, pages={10446-50} }