Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice.

@article{Goumans2000FunctionalAO,
  title={Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice.},
  author={Marie Jose T. H. Goumans and Christine L Mummery},
  journal={The International journal of developmental biology},
  year={2000},
  volume={44 3},
  pages={253-65}
}
During recent years, our understanding of TGFbeta signalling through serine/threonine kinase receptors and Smads has increased enormously. Activation of R-Smads by receptor induced phosphorylation is followed by complex formation with co-Smads and translocation to the nucleus, where the transcription of specific genes is affected and ultimately results in… CONTINUE READING