Functional analysis of the Burkholderia cenocepacia J2315 BceAJ protein with phosphomannose isomerase and GDP-d-mannose pyrophosphorylase activities

@article{Sousa2008FunctionalAO,
  title={Functional analysis of the Burkholderia cenocepacia J2315 BceAJ protein with phosphomannose isomerase and GDP-d-mannose pyrophosphorylase activities},
  author={S{\'i}lvia A Sousa and Leonilde M Moreira and Jorge H Leit{\~a}o},
  journal={Applied Microbiology and Biotechnology},
  year={2008},
  volume={80},
  pages={1015-1022}
}
The bceA J gene from the cystic fibrosis isolate Burkholderia cenocepacia J2315 encodes a 56-kDa bifunctional protein, with phosphomannose isomerase (PMI) and guanosine diphosphate (GDP)-mannose pyrophosphorylase (GMP) activities, a new member of the poorly characterised type II PMI class of proteins. Due to the lack of homology between the type II PMIs and the human PMI, this class of proteins are being regarded as interesting potential targets to develop new antimicrobials. The BceAJ protein… CONTINUE READING

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