Functional analysis of seven genes encoding eight translation initiation factor 4E (eIF4E) isoforms in Drosophila

@article{Hernndez2005FunctionalAO,
  title={Functional analysis of seven genes encoding eight translation initiation factor 4E (eIF4E) isoforms in Drosophila},
  author={G Bernal Hern{\'a}ndez and Michael Wrentschur Peter Altmann and Jos{\'e} Manuel Mart{\'i}nez Sierra and Henning Urlaub and Ruth D{\'i}ez del Corral and Peter H. Schwartz and Rolando Rivera-Pomar},
  journal={Mechanisms of Development},
  year={2005},
  volume={122},
  pages={529-543}
}
The Drosophila genome-sequencing project has revealed a total of seven genes encoding eight eukaryotic initiation factor 4E (eIF4E) isoforms. Four of them (eIF4E-1,2, eIF4E-3, eIF4E-4 and eIF4E-5) share exon/intron structure in their carboxy-terminal part and form a cluster in the genome. All eIF4E isoforms bind to the cap (m7GpppN) structure. All of them, except eIF4E-6 and eIF4E-8 were able to interact with Drosophila eIF4G or eIF4E-binding protein (4E-BP). eIF4E-1, eIF4E-2, eIF4E-3, eIF4E-4… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 82 REFERENCES

Purification and characterization of eukaryotic polypeptide chain initiation factor 4F from Drosophila melanogaster embryos

J. M. Zapata, M. A. Martı́nez, J. M. Sierra
  • J. Biol. Chem
  • 1994
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

An overview of Ensembl

E. Birney
  • Genome Res
  • 2004
VIEW 12 EXCERPTS
HIGHLY INFLUENTIAL

Isolation and characterization of the cDNA and the gene for eukaryotic translation initiation factor 4G from Drosophila melanogaster

G. Hernández, M. M. Castellano, M. Agudo, J. M. Sierra
  • Eur. J. Biochem
  • 1998
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL