Functional analysis of neutralizing antibodies against Clostridium perfringens epsilon-toxin.

@article{McClain2007FunctionalAO,
  title={Functional analysis of neutralizing antibodies against Clostridium perfringens epsilon-toxin.},
  author={Mark S McClain and Timothy L Cover},
  journal={Infection and immunity},
  year={2007},
  volume={75 4},
  pages={1785-93}
}
The Clostridium perfringens epsilon-toxin causes a severe, often fatal illness (enterotoxemia) characterized by cardiac, pulmonary, kidney, and brain edema. In this study, we examined the activities of two neutralizing monoclonal antibodies against the C. perfringens epsilon-toxin. Both antibodies inhibited epsilon-toxin cytotoxicity towards cultured MDCK cells and inhibited the ability of the toxin to form pores in the plasma membranes of cells, as shown by staining cells with the membrane… CONTINUE READING
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