Functional analysis of methyltransferases participating in streptothricin-related antibiotic biosynthesis.

Abstract

Streptothricin (ST) and its related compounds produced by Streptomyces strains are broad-spectrum antibiotics that consist of carbamoylated d-gulosamine, amino-acid side chain, and streptolidine lactam moieties. BD-12, a streptothricin-related antibiotic, has a glycine-derived side chain and two N-methyl groups, whereas ST-F carrying the l-β-lysine side… (More)
DOI: 10.1016/j.jbiosc.2017.09.004

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