Functional analysis of mRNA scavenger decapping enzymes.

@article{Liu2004FunctionalAO,
  title={Functional analysis of mRNA scavenger decapping enzymes.},
  author={Shin-Wu Liu and Xinfu Jiao and Hudan Liu and Meigang Gu and Christopher D Lima and Megerditch Kiledjian},
  journal={RNA},
  year={2004},
  volume={10 9},
  pages={
          1412-22
        }
}
Eukaryotic cells primarily utilize exoribonucleases and decapping enzymes to degrade their mRNA. Two major decapping enzymes have been identified. The hDcp2 protein catalyzes hydrolysis of the 5' cap linked to an RNA moiety, whereas the scavenger decapping enzyme, DcpS, functions on a cap structure lacking the RNA moiety. DcpS is a member of the histidine triad (HIT) family of hydrolases and catalyzes the cleavage of m7GpppN. HIT proteins are homodimeric and contain two conserved 100-amino-acid… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 35 CITATIONS

Dual nuclear roles of an essential scavenger decapping enzyme

VIEW 11 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 36 REFERENCES

The hDcp2 protein is a mammalian mRNA decapping enzyme.

VIEW 9 EXCERPTS