Functional analysis of human replication protein A in nucleotide excision repair.

  title={Functional analysis of human replication protein A in nucleotide excision repair.},
  author={E Stigger and Rachid Drissi and Sang H Lee},
  journal={The Journal of biological chemistry},
  volume={273 15},
Human replication protein A (RPA) is a three-subunit protein complex (70-, 34-, and 11-kDa subunits) involved in DNA replication, repair, and recombination. Both the 70- (p70) and 34-kDa (p34) subunits interact with Xeroderma pigmentosum group A complementing protein (XPA), a key protein involved in nucleotide excision repair. Our deletion analysis indicated that no particular domain(s) of RPA p70 was essential for its interaction with XPA, whereas 33 amino acids from the C terminus of p34… CONTINUE READING

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