Functional analysis of human T cell subsets defined by CD45 isoform expression.

@article{Beverley1992FunctionalAO,
  title={Functional analysis of human T cell subsets defined by CD45 isoform expression.},
  author={Peter Beverley},
  journal={Seminars in immunology},
  year={1992},
  volume={4 1},
  pages={35-41}
}
The properties of human CD45RA and CD45RO T cells are described. CD45RO cells respond to recall antigens and provide help for B lymphocytes. They produce a wide variety of cytokines including IL-2, IL-4 and IFN-gamma. CD45RA T cells respond poorly to recall antigens and produce mainly IL-2. The phenotype of CD45RO cells suggests that they may be in cycle and in vivo data shows that they have a short lifespan while CD45RA cells are long-lived. The lineage relationship of the two subsets is not… CONTINUE READING

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