Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer.

@article{Bernier1993FunctionalAO,
  title={Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer.},
  author={Denis Bernier and H{\'e}l{\`e}ne Thomassin and Denis Allard and Michel Guertin and D M Hamel and M Blaqui{\`e}re and Myriam Beauchemin and H{\'e}l{\`e}ne Larue and M Estable-Puig and L. L. Belanger},
  journal={Molecular and cellular biology},
  year={1993},
  volume={13 3},
  pages={1619-33}
}
During liver development, the tandem alpha 1-fetoprotein (AFP)/albumin locus is triggered at the AFP end and then asymmetrically enhanced; this is followed by autonomous repression of the AFP-encoding gene. To understand this regulation better, we characterized the two early developmental stage-specific DNase I-hypersensitive (DH) sites so far identified in rat liver AFP/albumin chromatin: an intergenic DH-enhancer site and the AFP DH-promoter site. Mutation-transfection analyses circumscribed… CONTINUE READING

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