Functional analysis of cis- and trans-acting replication factors of porcine circovirus type 1.

@article{Steinfeldt2007FunctionalAO,
  title={Functional analysis of cis- and trans-acting replication factors of porcine circovirus type 1.},
  author={Tobias Steinfeldt and Tim Finsterbusch and Annette Mankertz},
  journal={Journal of virology},
  year={2007},
  volume={81 11},
  pages={5696-704}
}
The replication proteins Rep and Rep' of porcine circovirus type 1 (PCV1) are both capable of introducing and resealing strand discontinuities at the viral origin of DNA replication in vitro underlying genome amplification by rolling-circle replication. The PCV1 origin of replication encompasses the minimal binding site (MBS) of the Rep and Rep' proteins and an inverted repeat with the potential to form a stem-loop. In this study, both elements of the PCV1 origin were demonstrated to be… CONTINUE READING
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