Functional analysis of carp interferon-gamma: evolutionary conservation of classical phagocyte activation.

@article{Arts2010FunctionalAO,
  title={Functional analysis of carp interferon-gamma: evolutionary conservation of classical phagocyte activation.},
  author={J. Arts and E. Tijhaar and M. Chadzinska and H. Savelkoul and B. M. V. Verburg-van Kemenade},
  journal={Fish \& shellfish immunology},
  year={2010},
  volume={29 5},
  pages={
          793-802
        }
}
In teleost fish two IFN-gamma gene sequences were found for which two phylogenetic clusters can be distinguished. Our previous analysis of expression of these in carp led us to hypothesize that a classical IFN-gamma function is associated with the IFN-gamma2 cluster. We investigated the evolutionary conservation of the IFN-gamma function, inducing classical activation of phagocytes, thus skewing towards a Th1-like profile of immune activation. Recombinant proteins for the carp IFN-gamma… Expand
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