Functional analysis of a promoter variant of the gene encoding the interferon-gamma receptor chain I

@article{Jliger2002FunctionalAO,
  title={Functional analysis of a promoter variant of the gene encoding the interferon-gamma receptor chain I},
  author={Simone J{\"u}liger and Martina Bongartz and Adrian J F Luty and Peter Gottfried Kremsner and J{\"u}rgen F. J. Kun},
  journal={Immunogenetics},
  year={2002},
  volume={54},
  pages={675-680}
}
We analyzed a single nucleotide polymorphism (SNP) at position −56 (T→C) in the promoter region of the gene encoding the human interferon-gamma receptor ligand-binding chain I (IFN-γR1). The mutation was present at similar frequencies in Gabonese children with either mild or severe malaria. Functional investigations of the promoter in a transfected human B-cell line showed lower levels of luciferase reporter gene expression in the presence of the mutation, indicating the importance of this… CONTINUE READING

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