Functional analysis of a polymorphism in the promoter region of the IL-12/23p40 gene.

@article{Shimokawa2009FunctionalAO,
  title={Functional analysis of a polymorphism in the promoter region of the IL-12/23p40 gene.},
  author={Noriaki Shimokawa and Chiharu Nishiyama and Tomomitsu Hirota and Mayumi Tamari and Mutsuko Hara and Sadao Ikeda and Ko Okumura and Hideoki Ogawa},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={2009},
  volume={39 2},
  pages={228-35}
}
BACKGROUND Human IL-12B gene on chromosome 5q31 encodes the common p40 subunit of IL-12 and IL-23. IL-12 is known to play critical roles in the generation of T-helper type 1 (TH(1)) cells, whereas IL-23 is involved in maintenance and/or population expansion of TH(17) cells. Although several reports suggested an association between a polymorphism (-6415CTCTAA/GC) in IL-12B and asthma, the molecular mechanism how this polymorphism is involved in allergic inflammation is still unclear. METHODS… CONTINUE READING