Functional analysis of a novel DNA polymorphism of a tandem repeated sequence in the asparagine synthetase gene in acute lymphoblastic leukemia cells.

@article{Akagi2009FunctionalAO,
  title={Functional analysis of a novel DNA polymorphism of a tandem repeated sequence in the asparagine synthetase gene in acute lymphoblastic leukemia cells.},
  author={Tadayuki Akagi and Dong Yin and Norihiko Kawamata and Claus Rainer Bartram and Wolf-K. Hofmann and Jee Hoon Song and Carl W. Miller and Monique L den Boer and H Phillip Koeffler},
  journal={Leukemia research},
  year={2009},
  volume={33 7},
  pages={991-6}
}
Asparagine synthetase (ASNS) is an enzyme expressed ubiquitously in mammalian cells. Here, we discovered two 14-bp tandem repeat (2R, wild-type) sequences in the first intron of the gene. The 14-bp sequence is similar to the three GC-boxes (GC-I, -II, and -III) found in the promoter region of the ASNS gene, as well as, the binding site of transcription factor Sp-1. Approximately 75% of acute lymphoblastic leukemia (ALL) samples had the 2R sequence in both allele; however, 20% and 3% ALL samples… CONTINUE READING
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