Functional analysis of a new polymorphism in the human TNF alpha gene promoter.

@article{Pociot1995FunctionalAO,
  title={Functional analysis of a new polymorphism in the human TNF alpha gene promoter.},
  author={Flemming Pociot and Sandra D'alfonso and Silvana Compasso and Raffaella Scorza and Patricia Momigliano Richiardi},
  journal={Scandinavian journal of immunology},
  year={1995},
  volume={42 4},
  pages={501-4}
}
In this paper the functional relevance of a TNFA promoter polymorphism, a G/A polymorphic sequence at position -238, was tested by analysing its influence on TNF alpha production upon in vitro stimulation of monocytes from 78 healthy, unrelated individuals by lipopolysaccharide (LPS) or after allogenic stimulation in a panel of 32 healthy individuals. All TNFA-A positive individuals were either DR3 or DR7 positive, confirming the previously reported strong linkage disequilibrium of the TNFA-A… CONTINUE READING