Functional analysis of a carboxyl-terminal phosphorylation mutant of the bovine papillomavirus E1 protein.

@article{Lentz2002FunctionalAO,
  title={Functional analysis of a carboxyl-terminal phosphorylation mutant of the bovine papillomavirus E1 protein.},
  author={Michael R Lentz and Thomas A. Zanardi and Robyn Filzen and Jena Carter and Maria Hella},
  journal={Journal of molecular biology},
  year={2002},
  volume={316 3},
  pages={599-609}
}
The papillomavirus E1 protein is essential for viral DNA replication, and phosphorylation of E1 appears to regulate protein function and DNA replication. Serine 584 of bovine papillomavirus E1 is in a conserved motif resembling a CK2 consensus site, and is phosphorylated by CK2 in vitro. Mutation of serine 584 to alanine eliminates replication of the viral… CONTINUE READING