Functional analysis of PU.1 domains in monocyte-specific gene regulation.

  title={Functional analysis of PU.1 domains in monocyte-specific gene regulation.},
  author={Chiharu Nishiyama and Makoto Nishiyama and Tomonobu Ito and Shigehiro Masaki and Nobutaka Masuoka and Hisakazu Yamane and Toshio Kitamura and Hideoki Ogawa and Ko Okumura},
  journal={FEBS letters},
  volume={561 1-3},
The Ets family transcription factor PU.1 is required for the development of various lymphoid and myeloid cell lineages, and regulates the expression of several genes in a cell type-specific manner. Recently we found that overproduction of PU.1 in mouse bone marrow-derived mast cell progenitors induced the expression of monocyte-specific genes. This prompted us to analyze the functions of each domain of PU.1 in monocyte-specific gene expression, using transfection of mast cell progenitors with a… CONTINUE READING


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