Functional analysis of PKD1 transgenic lines reveals a direct role for polycystin-1 in mediating cell-cell adhesion.

@article{Streets2003FunctionalAO,
  title={Functional analysis of PKD1 transgenic lines reveals a direct role for polycystin-1 in mediating cell-cell adhesion.},
  author={Andrew J. Streets and Linda J. Newby and M J O'hare and Nikolay O. Bukanov and Oxana Ibraghimov-Beskrovnaya and Albert C. M. Ong},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2003},
  volume={14 7},
  pages={1804-15}
}
The PKD1 protein, polycystin-1, is a large transmembrane protein of uncertain function and topology. To study the putative functions of polycystin-1, conditionally immortalized kidney cells transgenic for PKD1 were generated and an interaction between transgenic polycystin-1 and endogenous polycystin-2 has been recently demonstrated in these cells. This study provides the first functional evidence that transgenic polycystin-1 directly mediates cell-cell adhesion. In non-permeabilized cells… CONTINUE READING
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