Functional analysis of Hes-1 in preadipocytes.

@article{Ross2006FunctionalAO,
  title={Functional analysis of Hes-1 in preadipocytes.},
  author={David A Ross and Sridhar Hannenhalli and John W Tobias and Neil S Cooch and Ramin Shiekhattar and Tom Kadesch},
  journal={Molecular endocrinology},
  year={2006},
  volume={20 3},
  pages={
          698-705
        }
}
Notch signaling blocks differentiation of 3T3-L1 preadipocytes, and this can be mimicked by constitutive expression of the Notch target gene Hes-1. Although considered initially to function only as a repressor, recent evidence indicates that Hes-1 can also activate transcription. We show here that the domains of Hes-1 needed to block adipogenesis coincide with those necessary for transcriptional repression. HRT1, another basic-helix-loop-helix protein and potential Hes-1 partner, was also… CONTINUE READING

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