Functional analysis of Csk and CHK kinases in breast cancer cells.

@article{Bougeret2001FunctionalAO,
  title={Functional analysis of Csk and CHK kinases in breast cancer cells.},
  author={C{\'e}cile Bougeret and S Jiang and Iafa Keydar and Hava Karsenty Avraham},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 36},
  pages={33711-20}
}
In this report, we analyzed the expression and kinase activities of Csk and CHK kinases in normal breast tissues and breast tumors and their involvement in HRG-mediated signaling in breast cancer cells. Csk expression and kinase activity were abundant in normal human breast tissues, breast carcinomas, and breast cancer cell lines, whereas CHK expression was negative in normal breast tissues and low in some breast tumors and in the MCF-7 breast cancer cell line. CHK kinase activity was not… CONTINUE READING

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