Functional analysis by site-directed mutagenesis of the complex polymorphism in rat transporter associated with antigen processing.

@article{Deverson1998FunctionalAB,
  title={Functional analysis by site-directed mutagenesis of the complex polymorphism in rat transporter associated with antigen processing.},
  author={Edward V. Deverson and Louise Y. W. Leong and Angela Seelig and W. John Coadwell and Evelyn M. Tredgett and Geoffrey W Butcher and Jonathan Charles Howard},
  journal={Journal of immunology},
  year={1998},
  volume={160 6},
  pages={2767-79}
}
The transporter associated with Ag processing, TAP, is an endoplasmic reticulum resident heterodimeric member of the ATP-binding cassette transporter family. TAP transports short peptides from cytosol to the endoplasmic reticulum lumen for loading into recently synthesized class I MHC molecules. In the rat, two alleles of the TAP2 chain differ in their permissiveness to the transport of peptides with small hydrophobic, polar, or charged amino acids at the C terminus, and this correlates with… CONTINUE READING
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Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule

  • S. J. Powis, E. V. Deverson, +5 authors J. C. Howard
  • Nature
  • 1992
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