Functional analysis and transcriptional output of the Göttingen minipig genome

  title={Functional analysis and transcriptional output of the G{\"o}ttingen minipig genome},
  author={Tobias Heckel and Roland Schmucki and Marco Berrera and Stephan Ringshandl and Laura Badi and Guido Steiner and Morgane Ravon and Erich Kueng and Bernd Kuhn and Nicole A. Kratochwil and Georg Schmitt and Anna Kiialainen and Corinne Nowaczyk and Hamina Daff and Azinwi Phina Khan and Isaac Lekolool and Roger Pell{\'e} and Edward A. Okoth and Richard P. Bishop and Claudia A Daubenberger and Martin Ebeling and Ulrich Certa},
  booktitle={BMC Genomics},
In the past decade the Göttingen minipig has gained increasing recognition as animal model in pharmaceutical and safety research because it recapitulates many aspects of human physiology and metabolism. Genome-based comparison of drug targets together with quantitative tissue expression analysis allows rational prediction of pharmacology and cross-reactivity of human drugs in animal models thereby improving drug attrition which is an important challenge in the process of drug development. Here… CONTINUE READING