Functional analysis and transcriptional output of the Göttingen minipig genome

  title={Functional analysis and transcriptional output of the G{\"o}ttingen minipig genome},
  author={Tobias Heckel and R. Schmucki and M. Berrera and S. Ringshandl and L. Badi and Guido Steiner and M. Ravon and Erich K{\"u}ng and B. Kuhn and N. Kratochwil and G. Schmitt and A. Kiialainen and Corinne Nowaczyk and Hamina Daff and Azinwi Phina Khan and Isaac Lekolool and R. Pelle and E. Okoth and R. Bishop and C. Daubenberger and M. Ebeling and U. Certa},
  journal={BMC Genomics},
BackgroundIn the past decade the Göttingen minipig has gained increasing recognition as animal model in pharmaceutical and safety research because it recapitulates many aspects of human physiology and metabolism. Genome-based comparison of drug targets together with quantitative tissue expression analysis allows rational prediction of pharmacology and cross-reactivity of human drugs in animal models thereby improving drug attrition which is an important challenge in the process of drug… Expand
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