Functional analysis and molecular characterization of two acetylcholinesterases from the German cockroach, Blattella germanica

@article{Kim2010FunctionalAA,
  title={Functional analysis and molecular characterization of two acetylcholinesterases from the German cockroach, Blattella germanica},
  author={Y. Kim and J. Y. Choi and Y. Je and Y. Koh and S. Lee},
  journal={Insect Molecular Biology},
  year={2010},
  volume={19}
}
Two acetylcholinesterases (AChEs; BgAChE1 and BgAChE2) from Blattella germanica were functionally expressed using the baculovirus system. Kinetic analysis demonstrated that BgAChE2 had higher catalytic efficiency but lower substrate specificity than BgAChE1. With the exceptions of paraoxon and propoxur, BgAChE1 was generally less sensitive to inhibitors than BgAChE2. Western blot analysis using anti‐BgAChE antibodies revealed that BgAChE1 was far more abundant in all examined tissues compared… Expand
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