Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3.

@article{Hagen1995FunctionalAO,
  title={Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3.},
  author={Gisela Hagen and J Dennig and Anette Preiss and Miguel Beato and Guntram Suske},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 42},
  pages={24989-94}
}
Sp4 is a human sequence-specific DNA binding protein with structural features similar to those described for the transcription factors Sp1 and Sp3. These three proteins contain two glutamine-rich regions and a highly conserved DNA binding domain composed of three zinc fingers. Consistently, Sp1, Sp3, and Sp4 do have the same DNA binding specificities. In this report, we have embarked on a detailed analysis of the transcriptional properties of Sp4 in direct comparison to Sp1 and Sp3… CONTINUE READING