Functional analyses of lpr gene in MRL/Mp-lpr/lpr mice. Role of lymph node stromal cells in lpr-lymphadenopathy.

@article{OhnishiInoue1992FunctionalAO,
  title={Functional analyses of lpr gene in MRL/Mp-lpr/lpr mice. Role of lymph node stromal cells in lpr-lymphadenopathy.},
  author={Y Ohnishi-Inoue and Ryoji Yasumizu and Kikuya Sugiura and Naokazu Nagata and H X Fan and Naoki Oyaizu and Muneo Inaba and Junko Toki and Susumu Ikehara},
  journal={Immunobiology},
  year={1992},
  volume={186 5},
  pages={449-65}
}
To clarify the mechanism by which the lpr gene causes lymphadenopathy, we established an experimental system to induce lymph node (LN) swelling in unaffected mice. In MRL-(+)/+ mice that had been 5 Gy-irradiated and grafted with bone marrow cells (BMCs) plus LN from MRL-lpr/lpr mice, a remarkable enlargement of the LN grafts was seen. The enlarged grafts… CONTINUE READING