Functional amyloids as natural storage of peptide hormones in pituitary secretory granules.

  title={Functional amyloids as natural storage of peptide hormones in pituitary secretory granules.},
  author={Samir K Maji and Marilyn H. Perrin and Michael R. Sawaya and Sebastian Jessberger and Krishna C. Vadodaria and Robert A Rissman and Praful S Singru and K Peter R Nilsson and Rozalyn Simon and David Schubert and David S Eisenberg and Jean Rivier and Paul E Sawchenko and Wylie Vale and Roland Riek},
  volume={325 5938},
Amyloids are highly organized cross-beta-sheet-rich protein or peptide aggregates that are associated with pathological conditions including Alzheimer's disease and type II diabetes. However, amyloids may also have a normal biological function, as demonstrated by fungal prions, which are involved in prion replication, and the amyloid protein Pmel17, which is involved in mammalian skin pigmentation. We found that peptide and protein hormones in secretory granules of the endocrine system are… CONTINUE READING
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