Functional amyloid formation by Streptococcus mutans.

  title={Functional amyloid formation by Streptococcus mutans.},
  author={Muna Oli and Henry N Otoo and Paula J. Crowley and Kyle P Heim and Marcelle M Nascimento and Caleen B. Ramsook and Peter N Lipke and L. Jeannine Brady},
  volume={158 Pt 12},
Dental caries is a common infectious disease associated with acidogenic and aciduric bacteria, including Streptococcus mutans. Organisms that cause cavities form recalcitrant biofilms, generate acids from dietary sugars and tolerate acid end products. It has recently been recognized that micro-organisms can produce functional amyloids that are integral to biofilm development. We now show that the S. mutans cell-surface-localized adhesin P1 (antigen I/II, PAc) is an amyloid-forming protein. This… CONTINUE READING