Functional alterations of the nigrostriatal dopamine system in estrogen receptor-alpha knockout (ERKO) mice.

@article{Kueppers2008FunctionalAO,
  title={Functional alterations of the nigrostriatal dopamine system in estrogen receptor-alpha knockout (ERKO) mice.},
  author={Eva Kueppers and Andre Krust and Pierre Chambon and Cordian Beyer},
  journal={Psychoneuroendocrinology},
  year={2008},
  volume={33 6},
  pages={832-8}
}
Estrogen represents an important factor for the development and function of the nigrostriatal dopamine system. Estrogen also controls sex-specific differentiation and activity of the nigrostriatal dopaminergic system. We used an estrogen receptor-alpha knockout (-/-) model (ERKO) to study the influence of this particular receptor subtype on the regulation of functional characteristics of the male and female nigrostriatal dopamine system. On the striatal level, we found a sex-specific regulation… CONTINUE READING