Functional alterations in endocrine pancreas of rats with different degrees of dexamethasone-induced insulin resistance.

@article{Rafacho2008FunctionalAI,
  title={Functional alterations in endocrine pancreas of rats with different degrees of dexamethasone-induced insulin resistance.},
  author={Alex Rafacho and Vanessa Aparecida Giozzet and Ant{\^o}nio Carlos Boschero and Jos{\'e} Roberto Bosqueiro},
  journal={Pancreas},
  year={2008},
  volume={36 3},
  pages={284-93}
}
OBJECTIVES We have analyzed the peripheral insulin and glucose sensitivity in vivo, and islet function ex vivo in rats with different degrees of insulin resistance induced by dexamethasone (DEX). METHODS Dexamethasone, in the concentrations of 0.1 (DEX 0.1), 0.5 (DEX 0.5), and 1.0 mg/kg body weight (DEX 1.0) was administered daily, intraperitoneally, to adult Wistar rats for 5 days, whereas controls received saline. RESULTS Dexamethasone treatment induced peripheral insulin resistance in a… CONTINUE READING
30 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

Similar Papers

Loading similar papers…