Functional alteration of the beta-adrenergic receptor during desensitization of mammalian adenylate cyclase by beta-agonists.

@article{Kassis1984FunctionalAO,
  title={Functional alteration of the beta-adrenergic receptor during desensitization of mammalian adenylate cyclase by beta-agonists.},
  author={Shouki Kassis and Peter Fishman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1984},
  volume={81 21},
  pages={6686-90}
}
Exposure of several mammalian cell lines to isoproterenol resulted in a desensitization of the beta-adrenergic receptor-adenylate cyclase system in membranes isolated from the cells. Under the experimental conditions chosen, desensitization was accompanied by a minimal loss of beta-receptors. The cells tested included HeLa, S49 cyc- lymphoma, and rat glioma… CONTINUE READING