Functional alteration of granulocytes, NK cells, and natural killer T cells in centenarians.

@article{Miyaji2000FunctionalAO,
  title={Functional alteration of granulocytes, NK cells, and natural killer T cells in centenarians.},
  author={Chikako Miyaji and Hisami Watanabe and Hiromu Toma and M Akisaka and Katschiro Tomiyama and Yasushi Sato and Toru Abo},
  journal={Human immunology},
  year={2000},
  volume={61 9},
  pages={908-16}
}
The immune system in centenarians was characterized as elevated levels in the proportion and number of granulocytes, NK cells, and extrathymic T cells (including NKT cells) in the peripheral blood. Conventional T cells, abundant in youth, were decreased in proportion and number. In addition to this numerical change in centenarians, the function was significantly altered in comparison with that in middle-aged subjects. The phagocytic function and cytokine production of granulocytes in… CONTINUE READING

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