Functional activity of serotoninergic and melatoninergic systems expressed in the skin

  title={Functional activity of serotoninergic and melatoninergic systems expressed in the skin},
  author={Andrzej T. Slominski and Alexander V. Pisarchik and Blazej Zbytek and Desmond J. Tobin and S{\"o}bia Kauser and Jacobo Wortsman},
  journal={Journal of Cellular Physiology},
We tested the expression of genes coding receptors of a cutaneous serotoninergic/melatoninergic system in whole human skin and in normal and pathologic cultured skin cells. Evaluation of serotonin (5HT), melatonin (MT), and melatonin‐related receptors (MRR) showed expression of the isoforms 5HT2B, 5HT7, and MT1 genes in almost all the tested samples. Expression of other isoforms was less prevalent; 5HT2C, MRR, and MT2 were rarely detected. We also found novel isoforms for MT2, MRR, and 5HT2B… 

Serotoninergic and melatoninergic systems are expressed in mouse embryonic fibroblasts NIH3T3 cells.

Evidence is provided that the NIH3T3 cells can synthesize intrinsic serotonin and melatonin and express key enzymes related biosynthetic pathways.

The cutaneous serotoninergic/melatoninergic system: securing a place under the sun

The widespread expression of a cutaneous seorotoninergic/melatoninergic system indicates considerable selectivity of action to facilitate intra‐, auto‐, or paracrine mechanisms that define and influence skin function in a highly compartmentalized manner.

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It seems that expression of the MT1 melatonin receptors benefits the efficacy of melatonin treatment, andMelatonin and its receptors may provide a promising way to establish new alternative therapeutic approaches in human cancer prevention.

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It is proposed that melatonin (synthesized locally or delivered topically) could counteract or buffer external (environmental) or internal stresses to preserve the biological integrity of the organ and to maintain its homeostasis.

Serotonin (5-HT) 2A Receptor Involvement in Melanin Synthesis and Transfer via Activating the PKA/CREB Signaling Pathway

It is demonstrated that HTR2A mediates the melanogenesis induction of its ligands by activating the PKA/CREB signaling pathway and supports that H TR2A could be designed as a drug target for the development of chemicals to treat cutaneous diseases with melanocytes or melanogenesis abnormality.

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Melatonin differentially suppressed proliferation in melanoma cell lines of different behaviour, suggesting the intensity of the oncostatic response to melatonin could be related to the cell-line specific pattern of melatonin cellular receptors and cytosolic binding protein expression.

A role of melatonin in neuroectodermal‐mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors

Melatonin‐like immunoreactivity (IR) is demonstrated in the outer root sheath of mouse and human hair follicles (HFs), which corresponds to melatonin, as shown by radioimmunoassay and liquid chromatography/tandem mass spectrometry.

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Serotoninergic and melatoninergic systems are fully expressed in human skin

Examination of cutaneous expression of genes and enzymes responsible for the multistep conversion of tryptophan to serotonin and further to melatonin provides evidence that the human skin expresses intrinsic serotonin and melatonin biosynthesis pathways.

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Melatonin inhibited the growth of uveal melanoma cell lines in a dose-dependent manner and the abnormal metabolite of tryptophan (kynurenine) did not inhibit thegrowth of the melanoma cells, indicating that changes to the metabolic processes of melatonin may play a role in the pathogenesis of uventus melanoma.

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The Mel1b melatonin receptor may mediate the reported actions of melatonin in retina and participate in some of the neurobiological effects ofmelatonin in mammals.

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Pharmacological and physiological studies have shown that the multiple actions of serotonin are mediated by several distinct cell surface receptor subtypes, designated SHTl a, Ib, lc, Id, SHT2,SHT3, and SHT4.

Melatonin regulates glucocorticoid receptor: an answer to its antiapoptotic action in thymus

The mechanism by which melatonin protects thymocytes from cell death induced by glucocorticoids is elucidated and the effects of melatonin on this receptor are proposed as the likely mediator of its thymocyte protection against dexamethasone‐induced cell death.