Functional activation of mutant human insulin receptor by monoclonal antibody.

@article{Krook1996FunctionalAO,
  title={Functional activation of mutant human insulin receptor by monoclonal antibody.},
  author={A. Krook and Maria A. Soos and Shant Kumar and Kenneth Siddle and Stephen O'Rahilly},
  journal={Lancet},
  year={1996},
  volume={347 9015},
  pages={1586-90}
}
BACKGROUND A mutant insulin receptor, Ser323Leu, has been reported in two severely insulin-resistant patients with Rabson-Mendenhall syndrome. In both cases, extreme hyperglycaemia could not be controlled by conventional antidiabetic therapy. The SER323Leu mutant insulin receptor is inserted normally in the plasma membrane but has very low binding affinity for insulin. A monoclonal antibody directed against the extracellular domain of the insulin receptor (83.14) can mimic the natural ligand as… CONTINUE READING

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