Functional abnormalities in vincristine-induced night blindness.

  title={Functional abnormalities in vincristine-induced night blindness.},
  author={Harris Ripps and Ronald E. Carr and Irwin M. Siegel and Vivienne C. Greenstein},
  journal={Investigative ophthalmology & visual science},
  volume={25 7},
Various noninvasive test procedures were used to evaluate retinal function in a patient who had become night blind following vincristine chemotherapy. The results obtained were strikingly similar to those reported previously in subjects with recessively inherited stationary night blindness; the dark-adaptation curve was monophasic (ie, no evidence of a scotopic branch), rhodopsin kinetics were entirely normal, and spectral threshold data revealed the presence of residual rod-mediated vision… CONTINUE READING
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