Functional UQCRC1 polymorphisms affect promoter activity and body lipid accumulation.

@article{Kunej2007FunctionalUP,
  title={Functional UQCRC1 polymorphisms affect promoter activity and body lipid accumulation.},
  author={Tanja Kunej and Zeping Wang and Jennifer J. Michal and Tyler F. Daniels and Nancy S. Magnuson and Zhihua Jiang},
  journal={Obesity},
  year={2007},
  volume={15 12},
  pages={2896-901}
}
Obesity and type 2 diabetes constitute leading public health problems worldwide. Studies have shown that insulin resistance affiliated with these conditions is associated with skeletal muscle lipid accumulation, while the latter is associated with mitochondrial dysfunctions. However, the initiation and regulation of mitochondrial biogenesis rely heavily on approximately 1000 nuclear-encoded mitochondrial regulatory proteins. In this study, we targeted the ubiquinol-cytochrome c reductase core… CONTINUE READING
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