Functional T cells in athymic nude mice.

  title={Functional T cells in athymic nude mice.},
  author={Susumu Ikehara and Rajendra N. Pahwa and Gabriel Henrique Barroso Viana Fernandes and Carl T. Hansen and Robert Alan Good},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={81 3},
After passage of spleen cells from nu/nu mice over a nylon wool column, concanavalin A-responsive cells can be detected in the presence of 2-mercaptoethanol, and specific cytotoxic T lymphocytes can be generated without exposure to interleukin 2 (IL-2). The spleen cells of the nu/nu mice born of nu/nu parents and nursed by nu/nu mothers had significantly fewer Thy-1+ T cells and a lesser capacity to generate cytotoxic T lymphocytes than did the conventionally bred nu/nu mice. Nonetheless, such… CONTINUE READING

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