Transferase and Carcinog
- B. Ketterer, K. H. Tan, D. J. Meyer, B. Glutahtione S Coles
- 1987
Functional Studies of Tyrosine 108 Residue in the Active Site of Human Glutathione S-Transferase P1-1
- Published 2005
Abstract
To gain further insight on the relationship between structure and functions of glutathione S-transferase (GST), the three tyrosine 108 mutants, Y108A, Y108F, and Y108W, of human GST P1-1 were expressed in Escherichia coli and purified to electrophoretic homogeneity by affinity chromatography on immobilized GSH. The substitution of Tyr 108 with alanine… (More)
Topics
- Glutathione
- Tyrosine
- Glutathione S-Transferase
- Tryptophan
- Alanine
- Phenylalanine
- Steroids
- Substitution
- Epoxy Compounds
- Transferase
- cumene hydroperoxide
- Chromatography, Affinity
- Residue after Decontamination Medical Device Problem
- glutathione peroxidase activity
- peroxidase activity
- Catalysis
- steroid delta-isomerase activity
- Androstenes