Functional Specialization of Presynaptic Cav2.3 Ca2+ Channels

  title={Functional Specialization of Presynaptic Cav2.3 Ca2+ Channels},
  author={Dirk Dietrich and Timo Kirschstein and Maria Kukley and Alexej Pereverzev and Christian von der Brelie and Toni Schneider and Heinz Beck},
Ca2+ influx into presynaptic terminals via voltage-dependent Ca2+ channels triggers fast neurotransmitter release as well as different forms of synaptic plasticity. Using electrophysiological and genetic techniques we demonstrate that presynaptic Ca2+ entry through Cav2.3 subunits contributes to the induction of mossy fiber LTP and posttetanic potentiation by brief trains of presynaptic action potentials while they do not play a role in fast synaptic transmission, paired-pulse facilitation, or… CONTINUE READING
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