Functional Selectivity of Hallucinogenic Phenethylamine and Phenylisopropylamine Derivatives at Human 5-Hydroxytryptamine (5-HT)2A and 5-HT2C Receptors
@article{Moya2007FunctionalSO, title={Functional Selectivity of Hallucinogenic Phenethylamine and Phenylisopropylamine Derivatives at Human 5-Hydroxytryptamine (5-HT)2A and 5-HT2C Receptors}, author={Pablo R. Moya and Kelly A Berg and Manuel A. Gutiérrez-Hernandez and Patricio S{\'a}ez-Briones and Miguel Reyes-Parada and Bruce K. Cassels and William P Clarke}, journal={Journal of Pharmacology and Experimental Therapeutics}, year={2007}, volume={321}, pages={1054 - 1061} }
2,5-Dimethoxy-4-substituted phenylisopropylamines and phenethylamines are 5-hydroxytryptamine (serotonin) (5-HT)2A/2C agonists. The former are partial to full agonists, whereas the latter are partial to weak agonists. However, most data come from studies analyzing phospholipase C (PLC)-mediated responses, although additional effectors [e.g., phospholipase A2 (PLA2)] are associated with these receptors. We compared two homologous series of phenylisopropylamines and phenethylamines measuring both…
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