Functional Selectivity of Hallucinogenic Phenethylamine and Phenylisopropylamine Derivatives at Human 5-Hydroxytryptamine (5-HT)2A and 5-HT2C Receptors

  title={Functional Selectivity of Hallucinogenic Phenethylamine and Phenylisopropylamine Derivatives at Human 5-Hydroxytryptamine (5-HT)2A and 5-HT2C Receptors},
  author={Pablo R Moya and Kelly A Berg and Manuel A. Guti{\'e}rrez-Hern{\'a}ndez and Patricio S{\'a}ez-Briones and Miguel Reyes-Parada and Bruce K. Cassels and William P Clarke},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={1054 - 1061}
  • P. MoyaK. Berg W. Clarke
  • Published 1 June 2007
  • Biology, Chemistry
  • Journal of Pharmacology and Experimental Therapeutics
2,5-Dimethoxy-4-substituted phenylisopropylamines and phenethylamines are 5-hydroxytryptamine (serotonin) (5-HT)2A/2C agonists. The former are partial to full agonists, whereas the latter are partial to weak agonists. However, most data come from studies analyzing phospholipase C (PLC)-mediated responses, although additional effectors [e.g., phospholipase A2 (PLA2)] are associated with these receptors. We compared two homologous series of phenylisopropylamines and phenethylamines measuring both… 

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