Functional SNPs in the lymphotoxin-α gene that are associated with susceptibility to myocardial infarction

@article{Ozaki2002FunctionalSI,
  title={Functional SNPs in the lymphotoxin-$\alpha$ gene that are associated with susceptibility to myocardial infarction},
  author={Kouichi Ozaki and Yozo Ohnishi and Aritoshi Iida and Akihiko Sekine and Ryo Yamada and Tatsuhiko Tsunoda and Hiroshi Sato and Hideyuki Sato and Masatsugu Hori and Yusuke Nakamura and Toshihiro Tanaka},
  journal={Nature Genetics},
  year={2002},
  volume={32},
  pages={650-654}
}
By means of a large-scale, case-control association study using 92,788 gene-based single-nucleotide polymorphism (SNP) markers, we identified a candidate locus on chromosome 6p21 associated with susceptibility to myocardial infarction. Subsequent linkage-disequilibrium (LD) mapping and analyses of haplotype structure showed significant associations between myocardial infarction and a single 50 kb halpotype comprised of five SNPs in LTA (encoding lymphotoxin-α), NFKBIL1 (encoding nuclear factor… 
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Results indicate that the altered expression of MIAT by the SNP may play some role in the pathogenesis of MI.
Lymphotoxin-α Gene and Risk of Myocardial Infarction in 6,928 Cases and 2,712 Controls in the ISIS Case-Control Study
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A meta-analysis found no significant association with CHD risk using a recessive model and only a modest association using a dominant model (with narrow confidence intervals around these risk estimates).
Genome-wide association study to identify SNPs conferring risk of myocardial infarction and their functional analyses
TLDR
Functional SNPs within the lymphotoxin-α gene (LTA) located on chromosome 6p21 that conferred susceptibility to myocardial infarction are identified and galectin-2 protein is identified as a binding partner of LTA protein.
An association study in essential hypertension using functional polymorphisms in lymphotoxin-alpha gene.
Haplotype-based association of four lymphotoxin-alpha gene polymorphisms with the risk of coronary artery disease in Han Chinese.
TLDR
A protective effect of the haplotype G-C-T-C on the occurrence of CAD is shown, suggesting the involvement of LTA in CAD pathogenesis.
Genetic Variation in the Lymphotoxin-Alpha Pathway and the Risk of Ischemic Stroke in European Populations
TLDR
Genetic variation in the lymphotoxin-α cascade (LTA, LGALS2, and PSMA6) is not a major risk factor for ischemic stroke, and none of these associations could be replicated in the UK population.
Functional variants in the lymphotoxin-alpha gene predict cardiovascular disease in dialysis patients.
TLDR
LTA and IL-6 gene variants independently predicted risk for CVD among dialysis patients, suggesting that susceptibility in multiple inflammatory pathways contribute to the development of CVD.
Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans.
TLDR
The finding that protective effects are linked with minor homozygous genotypes and haplotype 1 of the BAT1-NFKBIL1-LTA region in Europeans is opposite to the observation of associated risks in Japanese.
Polymorphisms in the Lymphotoxin Alpha Gene and the Risk of Ischemic Stroke in the Japanese Population
TLDR
A case-control study in a large Japanese population found neither the A252G nor C804A polymorphism of the LTA gene was associated with stroke overall and any subtypes of ischemic stroke in the Japanese population.
Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus
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It is suggested that TFAP2B might be a new candidate for conferring susceptibility to type 2 diabetes and contribute to the pathogenesis of type 2 Diabetes mellitus.
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