Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population

@article{Suzuki2008FunctionalSI,
  title={Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population},
  author={Akari Suzuki and Ryo Yamada and Yuta Kochi and Tetsuji Sawada and Yukinori Okada and Koichi Matsuda and Yoichiro Kamatani and Mikako Mori and Kenichi Shimane and Yasuhiko Hirabayashi and Atsushi Takahashi and Tatsuhiko Tsunoda and Akihiko Miyatake and Michiaki Kubo and Naoyuki Kamatani and Yusuke Nakamura and Kazuhiko Yamamoto},
  journal={Nature Genetics},
  year={2008},
  volume={40},
  pages={1224-1229}
}
Rheumatoid arthritis is a chronic autoimmune inflammatory disease with a complex genetic etiology. Members of the signaling lymphocyte activation molecule (SLAM) family carry out pivotal functions in innate immunity and in conventional lymphocytes. We identified a linkage disequilibrium block associated with rheumatoid arthritis in the chromosome 1q region containing multiple SLAM family genes. In this block, the association peaked at two functional SNPs (rs3766379 and rs6682654) in CD244 in… CONTINUE READING
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