Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population

  title={Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population},
  author={Akari Suzuki and Ryo Yamada and Yuta Kochi and Tetsuji Sawada and Yukinori Okada and Koichi Matsuda and Yoichiro Kamatani and Mikako Mori and Kenichi Shimane and Yasuhiko Hirabayashi and Atsushi Takahashi and Tatsuhiko Tsunoda and Akihiko Miyatake and Michiaki Kubo and Naoyuki Kamatani and Yusuke Nakamura and Kazuhiko Yamamoto},
  journal={Nature Genetics},
Rheumatoid arthritis is a chronic autoimmune inflammatory disease with a complex genetic etiology. Members of the signaling lymphocyte activation molecule (SLAM) family carry out pivotal functions in innate immunity and in conventional lymphocytes. We identified a linkage disequilibrium block associated with rheumatoid arthritis in the chromosome 1q region containing multiple SLAM family genes. In this block, the association peaked at two functional SNPs (rs3766379 and rs6682654) in CD244 in… CONTINUE READING
52 Citations
36 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 52 extracted citations


Publications referenced by this paper.
Showing 1-10 of 36 references

Genome - wide association study of 14 , 000 cases of seven common diseases and 3 , 000 shared controls

  • M. C. Hochberg
  • Nature
  • 2007

testing haplotype effects in association studies

  • D. A. Tregouet, Garelle, V. A new JAVA interface implementation of THESIAS
  • Bioinformatics 23, 1038–1039
  • 2007

Similar Papers

Loading similar papers…